Insulin-stimulated phosphorylation of protein phosphatase 1 regulatory subunit 12B revealed by HPLC-ESI-MS/MS
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چکیده
منابع مشابه
Quantification of phosphorylation of insulin receptor substrate-1 by HPLC-ESI-MS/MS.
Serine/threonine phosphorylation of insulin receptor substrate-1 (IRS-1) regulates the function and subsequent insulin signaling of this protein. Human IRS-1 has 1242 amino acid residues, including 182 serines and 60 threonines. The size, complexity, and relatively low abundance of this protein in biological samples make it difficult to map and quantify phosphorylation sites by conventional mea...
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ژورنال
عنوان ژورنال: Proteome Science
سال: 2012
ISSN: 1477-5956
DOI: 10.1186/1477-5956-10-52